Message: #278012
Аннета Эссекс » 12 Dec 2017, 21:30
Keymaster

Nonsteroid drugs used by athletes

the drug can be very dangerous and cause cardiac arrest if overdosed.

This is because potassium is responsible for maintaining the functioning of the heart muscle. The most common way to use the drug if convulsions are observed is one tablet every eight hours, for a total of three tablets per day. If not - one tablet a day, just to maintain muscle volume. The drug is used only if the athlete uses diuretics such as Lasix, and only for three to four days; three days before the competition and one - the competition. Side effects include upset stomach with nausea and vomiting. The drug also has a bad effect on the digestive tract as a whole and, with prolonged use, can cause ulcers. The dosage is determined by the doctor, individually, in order to avoid side effects. In

SOMATOTROPIN. There is no reference information yet, with the exception of untranslated (see below), there is a collective experience of application. "The course is basically half a year or less, usually on the eve of the competition in order to get into shape without any problems, because you can follow a fairly strict diet in terms of calories, and not worry about weight, because somatrope is a pronounced anti-catabolic. In Kolut mainly intramuscularly (less often - subcutaneously) 4 units per day, in the evening. On average, the cycle looks like this - 2 weeks every other day, then every day, and at the end again a week every other day. In parallel, there is a usual course of methane and retabolil - on one don’t expect a strong pruha hormone, but with steroids - just a bomb!

A few important points: You draw the solvent into the syringe, and gently piercing the cork in the bottle, very carefully, pour it along the wall of the bottle! Then, holding the vial between the open palms, very carefully and smoothly twist until the substance is completely dissolved. If you twist for a long time, and the solution is still cloudy, throw it away, because it's crap. Do not shake at all!!! Seriously, you can ruin it!
Questionable information: They say that if you are on a hormone, you should not take heavy weights, do biceps with supination, place your toes apart when squatting, etc. because supposedly bones can be bent. In my opinion, this is complete nonsense, but you need to keep in mind. It seems to be everything.

Sigma Product Information Sheet
SOMATOTROPIN from human pituitaries

Sigma product number S4776 (formerly S1774)
Unless otherwise noted, the information below has been provided by our supplier.

CAS NUMBER:

9002-72-6 for somatotropin in general;

12629-01-5 for human growth hormone(1,2,4)

SYNONYMS:(1,2,4)

somatropin; adenohypophyseal growth hormone; GH; anterior pituitary growth hormone; somatotropic hormone; STH; human growth hormone; HGH; Bio-Tropin; CB 311; Corpormon; Crescormon; Genotropin; Humatrope; LY 137998; norditropin; Saizen; S.J.0011; Somatogen

GENERAL REMARKS:
Somatotropin is the major growth hormone, produced in the anterior lobe of pituitary glands in mammals, and in humans is approximately 10% of the dry weight of the gland. The human growth hormone is sometimes given the more specific name "somatropin", with the CAS number 12629-01-5(1,2,4), although the growth hormone may also be referenced by species-specific or (for recombinant forms) source-specific CAS numbers.
An untreated deficiency of the hormone produces dwarfism. Excessive hormone produced before puberty results in gigantism; if excessive hormone is produced after puberty, the resulting condition is called acromegaly. Treatment with HGH (natural or recombinant) or an analog "somatrem" can be effective; somatrem differs by an additional methionine residue5 and may be more antigenic.(1)

STRUCTURE, PHYSICAL PROPERTIES:
The structure of human somatotropin is reported as either 190(3) or 191(1,2,4) amino acid residues with two disulfide bridges (at 53/165 and 182/189), with molecular weight of approximately 22 kDa. The isoelectric point (pI) has been reported as 4.9.(2,3) Neither pI nor molecular weight have been verified by Sigma. The reported sequences for somatotropin and somatrem are provided for comparison on the end of this document.

DESCRIPTION OF THE PRODUCT AS SOLD:
Each vial of S4776 contains 2 mg somatotropin, 0.1 mg ammonium hydrogen carbonate and 3.5 mg mannitol, lyophilized from a solution at pH 7.95. (Product S1774 from the same supplier was offered in a different buffer.) Contamination by other glycoproteins is low, but is no longer reported for each lot. (Typical values ​​for S1774, reported as maximum: h-luteinizing hormone, 1%; h-thyroid stimulating hormone, 1%; h-follicle stimulating hormone, 1%; h-prolactin, 2%; h-ACTH, 1%). (3)
This growth hormone was standardized against a World Health Organization Standard (stated on certificate of analysis). Its activity was measured by radioimmunoassay using an antiserum raised in a rabbit by immunization with eliminated human growth hormone. In one ampule of the first International Standard (1987), "4.4 units of human growth hormone (somatropin) are contained in 1.75 mg of freeze-dried pure human growth hormone, with 20 mg of glycine, 2 mg of mannitol, 2 mg of lactose and 2 mg of sodium bicarbonate".(1) Product S4776 typically has approximately 2 International Units (I.U.) per mg protein.

STABILITY:
Somatotropin should be stable in the lyophilized form for at least a year.

SOLUTIONS:
The contents of a vial should be dissolved with 1 mL of deionized water by gentle mixing (swirling). This solution can then be stored between 2-8?C for 3-4 weeks. Solutions should not be frozen and thawed.

REFERENCES:
MARTINDALE: THE EXTRA PHARMACOPOEIA, 30th Ed., p. 965 (1993). This reference gives extensive information regarding human usage, which should be generally helpful, although Sigma products are not to be used on humans, only for laboratory work.
MERCK INDEX, 11th Ed., #8672 (1989). This monograph contains numerous references for method of isolation, synthesis, usage, etc. Supplier information CHEMICAL ABSTRACTS SEARCH (CAS); Registry information, ACS (1995). From CAS Registry, CAS# 82030-87-3, the Index name is Somatotropin (human), N-L-methionyl-(9CI). "Somatrem" is a synonym for the methionyl derivative of human growth hormone, as well as Methionyl human growth hormone, Protropin and Somatonorm.

Teslac (Teslac, testolactone)
The drug is available in tablets of 250 mg. It is similar in structure to androgenic steroids, but does not show androgenic properties. It is an estrogen antagonist and is indicated for use in women with breast cancer. Athlete-chemists use it to prevent the effects of high estrogen levels caused by the use of easily aromatizing steroids. It is considered quite effective in its effects, but some prefer Nolvadex. Rarely appears on the black market. An effective dosage is 500 to 1000 mg per day. Side effects at this and even higher dosages have not been identified.

Thiomukaz
The drug was originally developed for use as a dispersing agent. When used at the injection site of a drug (a steroid, for example), it accelerates the absorption of the drug into the metabolic system, which increases its (drug) effectiveness. Bodybuilders use the drug to locally fight excess fat. Available in liquid form, injected with a syringe with a thin needle into the problem area. Except того, выпускается крем, для нанесения на кожу. Some people combine the drug with DMSO (DMSO - what is it?), and there is an improvement in results compared to the pure drug. Another form of release is tablets. Принимаются несколько раз в день за пару недель перед competitions. Some consider tablets not the most effective form of the drug. And another form of release - candles. Применяются дважды в день в течение недели перед competitions. Often several forms are used at the same time. Most athletes characterize the drug as effective, but for some reason it either works well or does not work at all. The drug works best in athletes with excessive water retention in fat cells, the result of the action of estrogen. Allows you to get rid of 20% of the water in the fat layer. This makes the area with excess fat look more "dry". Some time ago, the drug was widely distributed on the market, now it is difficult to find it.

Trisoralen (Trisoralen, trioxsalen)
The drug is often used by bodybuilders to improve tanning. Issued in tablets of 5 mg, 20 or 100 tablets per pack. Deep dark tan is highly valued by athletes. It visually makes the muscles larger and firmer and gives the body a more "dry" look. Usually the drug is used to combat vitiligo (vitiligo), a condition in which skin pigmentation disappears. This is its usual use, but doctors prescribe the drug to people with very fair skin who are going somewhere in the tropics. The drug increases resistance to sunlight and improves pigmentation. In the body, apparently, the drug affects melanin, which is responsible for the natural pigmentation of the skin. The drug only works if applied just before sun exposure. You can not use the drug for longer than 14 days and in a total amount of more than 28 tablets. This means two 10mg tablets taken 2-4 hours before sun exposure or tanning beds for 14 consecutive days. Neither the dosage nor the time of application can be increased more than indicated. There should be at least 4 weeks between courses. The drug does not help with sunburn, it just increases the rate of darkening of the skin. The toxicity of the drug has not been identified. Almost all athletes who used the drug note one or another degree of effectiveness. In fair-skinned people, the effect is more pronounced.

Cyclofenil (Cyclofenil)
Cyclofenil is another non-steroidal drug popular among bodybuilders. Similar in action to HCG (gonadotropin) and Clomid (Clomid). The drug is mainly used to enhance the natural production of testosterone after the end of the steroid cycle. This is necessary in order to avoid a sharp drop in volumes during the period of restoration of the natural level of hormones in the body. Just like HCG and Clomid, Cyclofenil raises natural testosterone quickly and effectively. However, Cyclofenil is somehow considered the weakest

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